ORC6 marks a replication-active malignant epithelial state and is associated with immune-low features in oral squamous cell carcinoma - Takeaways - MDSpire

ORC6 Identifies a Malignant Epithelial State with Active Replication and Correlates with Low Immune Features in Oral Squamous Cell Carcinoma

  • By

  • Shaofu Yan

  • Wenqi Tan

  • Yanxin Zhang

  • Jinyan Si

  • Jiehua Guo

  • Bo Yang

  • Jing Shi

  • July 21, 2026

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  • 1

    ORC6 is upregulated in oral squamous cell carcinoma (OSCC) and correlates with adverse clinicopathological features and poorer survival.

  • 2

    Single-cell analysis reveals ORC6 enrichment in malignant epithelial cells, indicating a replication-active state in OSCC.

  • 3

    High ORC6 expression is associated with activation of DNA-replication and cell-cycle programs, while showing weaker immune-related transcriptional signatures.

  • 4

    At the bulk-tumor level, ORC6 inversely correlates with immune-related features, including cytolytic activity and antigen-presentation signatures.

  • 5

    ORC6 knockdown in CAL27 cells reduces growth and migration while increasing antigen-presentation-associated transcripts and surface HLA expression.

Original Source(s)

ORC6 marks a replication-active malignant epithelial state and is associated with immune-low features in oral squamous cell carcinoma

  • by Shaofu Yan, Wenqi Tan, Yanxin Zhang, Jinyan Si, Jiehua Guo, Bo Yang, Jing Shi

  • July 21, 2026

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