Universal Risk Stratification in Stage I–III Cutaneous Melanoma Using 31-gene Expression Profiling: A Single-Center Study - Takeaways - MDSpire
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Comprehensive Risk Assessment for Stage I–III Cutaneous Melanoma Through 31-Gene Expression Profiling: Insights from a Single-Center Investigation

  • By

  • Daniel B. Gehle

  • Philip W. Morgan

  • Emme M. Fitts

  • Nathaniel L. Hauser

  • Chelsea R. Olson

  • Andrew M. Fleming

  • Julia Pedo Freitas

  • Feng Liu-Smith

  • Simonne S. Nouer

  • Andrew J. Murphy

  • Martin D. Fleming

  • June 1, 2026

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  • 1

    The study investigates the performance of the 31-gene expression profiling assay in predicting outcomes for patients with cutaneous melanoma.

  • 2

    Gene expression profiling has emerged as a prognostic tool, aiming to improve risk stratification for patients with early-stage cutaneous melanoma.

  • 3

    The 31-GEP assay may help identify low-risk patients who could avoid sentinel lymph node biopsy, particularly in older individuals with T1b-T2 lesions.

  • 4

    Integration of gene expression profiling into standard care remains controversial due to limitations in existing literature and lack of independent validation.

  • 5

    The study aims to validate the DecisionDx 31-GEP assay in a large, unselected cohort to address concerns regarding its clinical utility.

Original Source(s)

Universal Risk Stratification in Stage I–III Cutaneous Melanoma Using 31-gene Expression Profiling: A Single-Center Study

  • by Daniel B. Gehle, Philip W. Morgan, Emme M. Fitts, Nathaniel L. Hauser, Chelsea R. Olson, Andrew M. Fleming, Julia Pedo Freitas, Feng Liu-Smith, Simonne S. Nouer, Andrew J. Murphy, Martin D. Fleming

  • June 1, 2026

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