Combined immunohistochemistry and FISH testing for diagnosing metaplastic thymoma: a case report of misdiagnosis as pulmonary mucinous epidermoid carcinoma - Takeaways - MDSpire

Combined immunohistochemistry and FISH testing for diagnosing metaplastic thymoma: a case report of misdiagnosis as pulmonary mucinous epidermoid carcinoma

  • By

  • Jiaxin Liu

  • Xiang Yu

  • Wenquan Li

  • Chunhui Shen

  • Zhenhui Wang

  • Jiyong Wang

  • June 24, 2026

  • 0 min

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  • 1

    Metaplastic thymoma is a rare subtype of thymoma, accounting for less than 1% of all thymoma types.

  • 2

    The study highlights the importance of immunohistochemistry and FISH testing in accurately diagnosing metaplastic thymoma.

  • 3

    A case of metaplastic thymoma was misdiagnosed as pulmonary mucoepidermoid carcinoma due to overlapping clinical features.

  • 4

    Histological examination revealed nests of benign epithelioid and spindle cells with specific immunohistochemical markers.

  • 5

    Molecular testing identified YAP1-MAML2 gene rearrangement, aiding in the differentiation from pulmonary mucoepidermoid carcinoma.

Original Source(s)

Combined immunohistochemistry and FISH testing for diagnosing metaplastic thymoma: a case report of misdiagnosis as pulmonary mucinous epidermoid carcinoma

  • by Jiaxin Liu, Xiang Yu, Wenquan Li, Chunhui Shen, Zhenhui Wang, Jiyong Wang

  • June 24, 2026

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