Awakening antitumour immunity in the multimorbid host: a hypothesis coupling cryoablation-induced immunogenic cell death with multi-target Traditional Chinese Medicine - Takeaways - MDSpire
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Stimulating Antitumor Immunity in Patients with Multiple Chronic Conditions: A Proposal Integrating Cryoablation-Induced Immunogenic Cell Death and Multi-Target Traditional Chinese Medicine

  • By

  • Lihui Liu

  • Honglin Chen

  • Jingxiao Wang

  • Jingjing Yang

  • Yong Zhou

  • Baoping Luo

  • Yana Zhou

  • Kaiwen Hu

  • August 24, 2026

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  • 1

    Cancer primarily affects older adults with multiple chronic conditions, leading to an immunosuppressive inflammatory environment.

  • 2

    Cryoablation induces immunogenic cell death, promoting dendritic-cell maturation and CD8+ T-cell priming.

  • 3

    Multi-target Traditional Chinese Medicine (TCM) reduces inflammatory signaling and remodulates the tumor microenvironment.

  • 4

    The proposed Tumour Green Therapy framework integrates cryoablation and TCM to enhance antitumor immunity and reduce treatment burden.

  • 5

    The hypothesis requires prospective validation and aims to transform 'cold' tumors into 'hot' tumors while maintaining quality of life.

Original Source(s)

Awakening antitumour immunity in the multimorbid host: a hypothesis coupling cryoablation-induced immunogenic cell death with multi-target Traditional Chinese Medicine

  • by Lihui Liu, Honglin Chen, Jingxiao Wang, Jingjing Yang, Yong Zhou, Baoping Luo, Yana Zhou, Kaiwen Hu

  • August 24, 2026

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