Assessment of Varicella Vaccine Efficacy Amidst an Outbreak in a Chinese High School: A Retrospective Cohort Analysis

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The study evaluated the vaccine effectiveness of single-dose and two-dose varicella vaccines during a varicella outbreak in a Chinese high school.
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The overall varicella attack rate among 1,862 students during the outbreak was 6.29%, with significant differences in cumulative varicella-free survival.
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Vaccine effectiveness was 32.14% for single-dose recipients and 94.74% for two-dose recipients compared to unvaccinated individuals.
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Logistic regression indicated that male students had a higher risk of varicella, and prior two-dose vaccination significantly reduced infection risk.
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The study recommends routine catch-up vaccination and timely post-exposure vaccination to control varicella outbreaks in school settings.

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