Interpreting elevated FRAP in critical illness: beyond antioxidant capacity - Takeaways - MDSpire

Interpreting elevated FRAP in critical illness: beyond antioxidant capacity

  • By

  • Xinru Tang

  • Sichu Liu

  • Hong Yuan

  • July 1, 2026

  • 0 min

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  • 1

    Elevated FRAP levels in critically ill patients correlate with shock severity, endothelial dysfunction, and increased 90-day mortality.

  • 2

    FRAP demonstrated discriminative performance comparable to APACHE II and remained independently associated with mortality after adjustments.

  • 3

    Increased FRAP may reflect the accumulation of reducing metabolites due to organ dysfunction rather than solely an antioxidant response.

  • 4

    The FRAP assay is influenced by various endogenous compounds, which are affected by pathophysiological processes in severe illness.

  • 5

    Future studies should combine FRAP with specific oxidative injury markers to clarify its role in redox compensation versus oxidative damage.

Original Source(s)

Interpreting elevated FRAP in critical illness: beyond antioxidant capacity

  • by Xinru Tang, Sichu Liu, Hong Yuan

  • July 1, 2026

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