Immunosuppression after pediatric liver transplantation may lead to early and prolonged acute thymic involution: findings from a pilot longitudinal study - Takeaways - MDSpire

Immunosuppression after pediatric liver transplantation may lead to early and prolonged acute thymic involution: findings from a pilot longitudinal study

  • By

  • Guillermo Costaguta

  • Brenda Dinatale

  • Itauá Leston Araujo

  • Wilson Savino

  • Fernando Alvarez

  • Oscar Bottasso

  • Ana Rosa Perez

  • Florencia Belén González

  • Alejandro Costaguta

  • June 26, 2026

  • 0 min

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  • 1

    The study assessed the impact of immunosuppressive therapy on thymic function in pediatric liver transplant recipients over one year.

  • 2

    Thymic output, measured by sjTRECs, significantly declined over the 12-month follow-up period.

  • 3

    The sj/βTREC ratio showed a significant reduction after 3 months post-transplant.

  • 4

    Thymic size decreased significantly at 3 months post-transplant, with partial recovery observed thereafter.

  • 5

    The findings indicate early and persistent changes in thymic function following immunosuppression in pediatric transplant recipients.

Original Source(s)

Immunosuppression after pediatric liver transplantation may lead to early and prolonged acute thymic involution: findings from a pilot longitudinal study

  • by Guillermo Costaguta, Brenda Dinatale, Itauá Leston Araujo, Wilson Savino, Fernando Alvarez, Oscar Bottasso, Ana Rosa Perez, Florencia Belén González, Alejandro Costaguta

  • June 26, 2026

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