Alzheimer Biomarkers Higher in Women

Researchers identify sex-specific differences in amyloid, tau, and brain structure during the seventh decade of life.

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Women in their 60s exhibit greater Alzheimer pathology compared to men, despite showing structural brain resilience.
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The study found higher amyloid and tau burdens in women, influenced by apolipoprotein E epsilon 4 carrier status.
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Women demonstrated greater cortical thickness in Alzheimer-affected regions, independent of various demographic factors.
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Multivariable analyses revealed women had higher global amyloid and tau burdens, but associations were affected by vascular health.
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The study's cross-sectional design limits causal inference, and further research is needed with larger, balanced cohorts.

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