Baseline gut microbiome features associated with fecal calprotectin response to exclusive enteral nutrition in pediatric Crohn’s disease - Takeaways - MDSpire

Baseline gut microbiome features associated with fecal calprotectin response to exclusive enteral nutrition in pediatric Crohn’s disease

  • By

  • Hongwei Zheng

  • Wenbiao Chen

  • June 8, 2026

  • 0 min

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  • 1

    Exclusive enteral nutrition (EEN) is an effective induction therapy for pediatric Crohn's disease, improving clinical and biochemical outcomes.

  • 2

    Baseline gut microbiome features may be associated with fecal calprotectin response during EEN, though estimates are imprecise.

  • 3

    Treatment with EEN resulted in significant changes in several gut genera and alterations in stool biochemical summaries.

  • 4

    The study utilized public pediatric cohorts to analyze microbiome changes and their relationship with fecal calprotectin.

  • 5

    Findings indicate that while microbiome shifts occur during EEN, the associations with clinical outcomes remain exploratory.

Original Source(s)

Baseline gut microbiome features associated with fecal calprotectin response to exclusive enteral nutrition in pediatric Crohn’s disease

  • by Hongwei Zheng, Wenbiao Chen

  • June 8, 2026

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