Tracing the clinicodermoscopic and histopathological evolution of acquired reactive perforating collagenosis: a case report - Takeaways - MDSpire
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Examining the Clinicodermoscopic and Histopathological Progression of Acquired Reactive Perforating Collagenosis: A Case Study

  • By

  • Jue Wang

  • Lizhu Chen

  • Xinlong Chen

  • Nuoyan Li

  • Mingling Chen

  • Zhifei Wen

  • June 16, 2026

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  • 1

    Acquired reactive perforating collagenosis (ARPC) is a rare perforating dermatosis often misdiagnosed before overt transepidermal elimination occurs.

  • 2

    A 64-year-old woman with a 3-year history of pruritic papules was initially misdiagnosed as having eczema, highlighting diagnostic challenges.

  • 3

    Dermoscopy of early lesions revealed distinct features, lacking classic signs of perforation, which aids in differentiating ARPC from other conditions.

  • 4

    Biopsy of early lesions showed abnormal collagen aggregation without transepidermal elimination, indicating a pre-perforating stage in ARPC.

  • 5

    The study provides evidence for a definable pre-perforating stage in ARPC, emphasizing the importance of recognizing early signs for accurate diagnosis.

Original Source(s)

Tracing the clinicodermoscopic and histopathological evolution of acquired reactive perforating collagenosis: a case report

  • by Jue Wang, Lizhu Chen, Xinlong Chen, Nuoyan Li, Mingling Chen, Zhifei Wen

  • June 16, 2026

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