Systemic factors associated with poor anatomical response to anti-VEGF therapy in patients with diabetic macular edema: evidence from a large clinical cohort - Takeaways - MDSpire

Systemic Influences Linked to Suboptimal Anatomical Outcomes Following Anti-VEGF Treatment in Diabetic Macular Edema Patients: Insights from a Large Clinical Cohort

  • By

  • Xinru Jia

  • Yan Shi

  • Mengxiang He

  • Dongwei Yao

  • Chengfei Lin

  • July 21, 2026

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  • 1

    Diabetic macular edema (DME) is a major cause of vision impairment globally, particularly affecting the working-age population.

  • 2

    This study analyzed 1,039 eyes from 691 DME patients receiving intravitreal Conbercept to assess anatomical response.

  • 3

    After three months of treatment, the median central macular thickness decreased significantly, indicating a reduction in edema.

  • 4

    Factors such as baseline central macular thickness, visual acuity, LDL-C, fasting blood glucose, and HbA1c were linked to treatment response.

  • 5

    The study highlights the importance of systemic metabolic status in determining anatomical outcomes in DME patients undergoing anti-VEGF therapy.

Original Source(s)

Systemic factors associated with poor anatomical response to anti-VEGF therapy in patients with diabetic macular edema: evidence from a large clinical cohort

  • by Xinru Jia, Yan Shi, Mengxiang He, Dongwei Yao, Chengfei Lin

  • July 21, 2026

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