Case Report: Overlapping multiple sclerosis and neuropsychiatric systemic lupus erythematosus with positive MOG-IgG: a case initially misdiagnosed as depression - Takeaways - MDSpire

Clinical Case Study: Coexisting Multiple Sclerosis and Neuropsychiatric Systemic Lupus Erythematosus with Positive MOG-IgG in a Patient Initially Diagnosed with Depression

  • By

  • Wan Wei

  • Tao Jin

  • Liuhai Zhang

  • Yumeng Sun

  • Yangyang Xu

  • Xiaoqin Hong

  • July 20, 2026

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  • 1

    A 69-year-old female patient was initially misdiagnosed with major depressive disorder before developing neurological symptoms.

  • 2

    Comprehensive evaluation revealed coexisting multiple sclerosis and neuropsychiatric systemic lupus erythematosus in the patient.

  • 3

    Brain MRI showed multifocal white matter lesions consistent with demyelination, while serologic tests indicated various autoimmune antibodies.

  • 4

    Cerebrospinal fluid examination confirmed intrathecal IgG synthesis, with positive serum MOG-IgG at a titer of 1:32.

  • 5

    The patient showed clinical improvement after treatment with glucocorticoids and hydroxychloroquine, alongside continued psychiatric care.

Original Source(s)

Case Report: Overlapping multiple sclerosis and neuropsychiatric systemic lupus erythematosus with positive MOG-IgG: a case initially misdiagnosed as depression

  • by Wan Wei, Tao Jin, Liuhai Zhang, Yumeng Sun, Yangyang Xu, Xiaoqin Hong

  • July 20, 2026

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