Therapeutic effect of modified meridian-guided acupoint pressing on lumbar facet joint osteoarthritis: an integrated microbiomics and metabolomics analysis - Takeaways - MDSpire

Therapeutic effect of modified meridian-guided acupoint pressing on lumbar facet joint osteoarthritis: an integrated microbiomics and metabolomics analysis

  • By

  • Yu Jiang

  • Wanan Qin

  • Li Wei

  • Yalian Liao

  • Gejin Wei

  • July 8, 2026

  • 0 min

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  • 1

    Modified Meridian-Guided Acupoint Pressing (MMGAP) significantly reduced inflammatory markers and improved histopathological outcomes in lumbar facet joint osteoarthritis (LFJ OA) rats.

  • 2

    MMGAP reshaped gut microbiota and serum metabolomic profiles, enhancing the mTOR signaling pathway in the context of LFJ OA treatment.

  • 3

    Fecal microbiota transplantation from MMGAP-treated rats replicated therapeutic effects, indicating the role of gut microbiota in treatment efficacy.

  • 4

    The mTORC1 inhibitor rapamycin demonstrated similar anti-inflammatory and analgesic effects as MMGAP in the LFJ OA model.

  • 5

    These findings provide preliminary evidence supporting MMGAP as a potential non-invasive intervention for degenerative joint diseases.

Original Source(s)

Therapeutic effect of modified meridian-guided acupoint pressing on lumbar facet joint osteoarthritis: an integrated microbiomics and metabolomics analysis

  • by Yu Jiang, Wanan Qin, Li Wei, Yalian Liao, Gejin Wei

  • July 8, 2026

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