Association between hypothyroidism, levothyroxine replacement and kidney function outcomes: a systematic review and meta-analysis - Takeaways - MDSpire

Association between hypothyroidism, levothyroxine replacement and kidney function outcomes: a systematic review and meta-analysis

  • By

  • Xichang Wang

  • Xueying Shang

  • Yang Li

  • Cihang Lu

  • Ying Shao

  • Dongyu Yang

  • Weiping Teng

  • Xiaoguang Shi

  • May 1, 2026

  • 0 min

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  • 1

    The systematic review included 46 studies examining the relationship between hypothyroidism, levothyroxine therapy, and kidney function.

  • 2

    Both non-specific hypothyroidism and subclinical hypothyroidism were significantly associated with chronic kidney disease (CKD) occurrence.

  • 3

    No significant correlation was found between hypothyroidism and the incidence of end-stage renal disease (ESRD) in patients with pre-existing kidney impairment.

  • 4

    Levothyroxine therapy did not show notable improvement in estimated glomerular filtration rate (eGFR) in patients with hypothyroidism.

  • 5

    Further large-scale randomized controlled trials are needed to clarify the relationship between hypothyroidism, levothyroxine therapy, and renal outcomes.

Original Source(s)

Association between hypothyroidism, levothyroxine replacement and kidney function outcomes: a systematic review and meta-analysis

  • by Xichang Wang, Xueying Shang, Yang Li, Cihang Lu, Ying Shao, Dongyu Yang, Weiping Teng, Xiaoguang Shi

  • May 1, 2026

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