Efficacy and safety of interventions for Fibromyalgia syndrome comorbid with Irritable bowel syndrome: systematic review - Takeaways - MDSpire

Efficacy and safety of interventions for Fibromyalgia syndrome comorbid with Irritable bowel syndrome: systematic review

  • By

  • Mai A. Elkalla

  • Yousef G. Ali

  • Mohamed M. Ewais

  • Ahmed S. Taha

  • Mohab Sherif

  • December 22, 2025

  • 0 min

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  • 1

    Fibromyalgia syndrome (FMS) and Irritable bowel syndrome (IBS) frequently coexist, complicating diagnosis and treatment.

  • 2

    Shared pathophysiological mechanisms between FMS and IBS include central sensitization, neuroinflammation, and gut-brain axis disturbances.

  • 3

    Current treatments for FMS and IBS include pregabalin, cyclobenzaprine, probiotics, and dietary modifications, but efficacy varies.

  • 4

    This systematic review evaluated oral interventions for FMS and IBS, focusing on pain reduction and secondary outcomes like depression.

  • 5

    The review adhered to PRISMA guidelines and included five randomized controlled trials after rigorous screening and data extraction.

Original Source(s)

Efficacy and safety of interventions for Fibromyalgia syndrome comorbid with Irritable bowel syndrome: systematic review

  • by Mai A. Elkalla, Yousef G. Ali, Mohamed M. Ewais, Ahmed S. Taha, Mohab Sherif

  • December 22, 2025

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