Folate Metabolism–Based Risk Stratification Identifies CYP27B1 as a Determinant of Tumor Progression in HNSCC

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Folate metabolism is linked to tumorigenesis in head and neck squamous cell carcinoma (HNSCC), highlighting the need for reliable biomarkers.
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An 11-gene folate metabolism–associated gene signature (FMRG_score) effectively stratifies HNSCC patients into distinct survival cohorts.
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The FMRG_score serves as an independent prognostic indicator and enhances predictive performance when combined with clinical parameters.
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High FMRG_score correlates with reduced anti-tumor immune infiltration and an immunosuppressive tumor microenvironment.
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CYP27B1 knockdown improves cisplatin sensitivity, suggesting folate metabolism's role as a metabolic–immune axis in HNSCC.

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