Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis - Takeaways - MDSpire

Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis

  • By

  • Maarten J Pruijt

  • E Andra Neefjes-Borst

  • Floris A E De Voogd

  • Marilyne M Lange

  • Christoph Teichert

  • Reimer J Janssen

  • Geert R D’Haens

  • Krisztina B Gecse

  • November 4, 2025

  • 0 min

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  • 1

    Submucosal hyper-echogenicity on intestinal ultrasound indicates fat deposition in ulcerative colitis patients.

  • 2

    Higher relative submucosal echogenicity is associated with non-response to anti-inflammatory treatment in ulcerative colitis.

  • 3

    In a cohort of 118 patients, submucosal thickening was the most responsive bowel wall layer assessed by intestinal ultrasound.

  • 4

    An RSE value greater than 108 grayscale values predicts a lack of treatment response in ulcerative colitis patients.

  • 5

    Histopathological analysis showed that submucosal fat and collagen deposition are significant in ulcerative colitis.

Original Source(s)

Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis

  • by Maarten J Pruijt, E Andra Neefjes-Borst, Floris A E De Voogd, Marilyne M Lange, Christoph Teichert, Reimer J Janssen, Geert R D’Haens, Krisztina B Gecse

  • November 4, 2025

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