Association of a data-driven nutrient risk score with incident rheumatoid arthritis in UK Biobank adults: a prospective cohort study - Takeaways - MDSpire

Association of a data-driven nutrient risk score with incident rheumatoid arthritis in UK Biobank adults: a prospective cohort study

  • By

  • Wang, Aimin

  • Gao, Wenfeng

  • Yang, Xinyu

  • Wang, Yanxia

  • Ma, Yonghua

  • Sun, Na

  • Wang, Suzhen

  • Wang, Peizhong Peter

  • Shi, Fuyan

  • May 7, 2026

  • 0 min

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  • 1

    The study analyzed the association between nutrient risk score (NRS) and the onset of rheumatoid arthritis (RA) in 161,725 UK Biobank participants.

  • 2

    A 1-unit increase in NRS was linked to a 96% higher risk of developing RA, with a hazard ratio of 1.96 after adjusting for covariates.

  • 3

    Stratified analyses indicated a stronger association between NRS and RA risk in individuals with short sleep duration and low physical activity.

  • 4

    Participants with high genetic risk and the highest NRS had nearly double the risk of incident RA compared to those with low genetic risk and lowest NRS.

  • 5

    Obesity was found to partially mediate the association between NRS and RA risk, suggesting NRS could aid in RA risk stratification and intervention.

Original Source(s)

Association of a data-driven nutrient risk score with incident rheumatoid arthritis in UK Biobank adults: a prospective cohort study

  • by Wang, Aimin , Gao, Wenfeng , Yang, Xinyu , Wang, Yanxia , Ma, Yonghua , Sun, Na , Wang, Suzhen , Wang, Peizhong Peter , Shi, Fuyan

  • May 7, 2026

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