Obesity’s Cancer Role Underestimated
A proposed framework highlights potential sources of bias in current estimates
By
Kerri Miller
March 26, 2026
1
Obesity's role in cancer risk is likely underestimated due to measurement limitations in epidemiologic studies.
2
The PLUS framework identifies factors that may bias obesity-related cancer risk estimates downward.
3
Prediagnostic weight loss significantly affects BMI measurements, leading to underestimation of cancer risk.
4
Using waist circumference may provide a better assessment of cancer risk associated with visceral fat.
5
Integrating obesity control into cancer prevention strategies could enhance public health outcomes.