Neuropeptide Pathways Associated with TRPV1 in Periodontitis and Peri-implantitis - Takeaways - MDSpire

Neuropeptide Pathways Associated with TRPV1 in Periodontitis and Peri-implantitis

  • By

  • Yunzhi Lin

  • Qingfei He

  • Jianzhao Ni

  • Songting Ye

  • Ling Chen

  • Yun Wu

  • Chaofan Zhang

  • April 29, 2026

  • 0 min

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  • 1

    Periodontitis and peri-implantitis are prevalent dental diseases influenced by microbial challenges and host immune responses.

  • 2

    The TRPV1-CGRP axis promotes protective effects like osteogenesis, while the SP-NK1R axis is linked to inflammation and osteoclast activation.

  • 3

    Periodontitis retains self-regulatory capacity through periodontal ligament-mediated neural feedback, unlike peri-implantitis.

  • 4

    Peri-implantitis is characterized by impaired neural innervation and foreign body reactions, leading to chronic inflammation.

  • 5

    Future therapies may target neuropeptide receptors and utilize biomimetic coatings to enhance neuro-osteo-immune interactions.

Original Source(s)

Neuropeptide Pathways Associated with TRPV1 in Periodontitis and Peri-implantitis

  • by Yunzhi Lin, Qingfei He, Jianzhao Ni, Songting Ye, Ling Chen, Yun Wu, Chaofan Zhang

  • April 29, 2026

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