Association of the hemoglobin glycation index with the large-artery atherosclerosis subtype in ischemic stroke: a dual-cohort study

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The hemoglobin glycation index (HGI) reflects discordance between measured HbA1c and glucose-predicted HbA1c in ischemic stroke patients.
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Lower HGI is independently associated with higher large-artery atherosclerosis (LAA) risk in ischemic stroke patients from two cohorts.
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In the MIMIC-IV cohort, lower HGI is linked to increased in-hospital mortality among ischemic stroke patients.
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HGI and stress hyperglycemia ratio (SHR) are strongly inversely correlated, indicating a relationship with adverse outcomes.
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Mendelian randomization did not provide significant genetic evidence linking HGI to large-artery atherosclerosis.

Frontiers In Neurology

by Xinyu Tong, Jianxiong Gu, Chuxin Lyu, Yichun Zhao, Lei Chen, Tianzhi Ren, Haoxin Wu, Lei Yu, Ying Rui
June 29, 2026

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