Associated factors and a risk prediction model for comorbid circadian rhythm sleep-wake disorders in patients with chronic fatigue syndrome: implications for early screening and sleep health management - Takeaways - MDSpire

Identifying Factors and Developing a Risk Assessment Model for Comorbid Circadian Rhythm Sleep-Wake Disorders in Chronic Fatigue Syndrome Patients: Insights for Early Detection and Sleep Health Strategies

  • By

  • Xiao Shao

  • Fan Yang

  • Le-le Qin

  • Jia-ning Shi

  • Min Chen

  • Wen-jin Ge

  • Tian-jun Jiang

  • Jing-wen Yue

  • Wen Feng

  • Jing-han Wang

  • Zhen-xian Zhang

  • July 20, 2026

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  • 1

    The study analyzed 610 chronic fatigue syndrome patients to identify factors associated with comorbid circadian rhythm sleep-wake disorders.

  • 2

    Among the training cohort, 48.7% of patients with chronic fatigue syndrome had comorbid circadian rhythm sleep-wake disorders.

  • 3

    Independent factors associated with increased incidence of circadian rhythm sleep-wake disorders included female sex and specific shift work schedules.

  • 4

    Increased slow-wave sleep was linked to decreased odds of developing comorbid circadian rhythm sleep-wake disorders.

  • 5

    The developed risk prediction model demonstrated good performance in both training and validation cohorts for early screening.

Original Source(s)

Associated factors and a risk prediction model for comorbid circadian rhythm sleep-wake disorders in patients with chronic fatigue syndrome: implications for early screening and sleep health management

  • by Xiao Shao, Fan Yang, Le-le Qin, Jia-ning Shi, Min Chen, Wen-jin Ge, Tian-jun Jiang, Jing-wen Yue, Wen Feng, Jing-han Wang, Zhen-xian Zhang

  • July 20, 2026

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