Diagnostic value of contrast-enhanced ultrasound combined with other imaging techniques in differentiating benign and malignant thyroid nodules: a network meta-analysis - Takeaways - MDSpire
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Evaluating the Diagnostic Efficacy of Contrast-Enhanced Ultrasound in Conjunction with Other Imaging Modalities for Distinguishing Benign from Malignant Thyroid Nodules: A Network Meta-Analysis

  • By

  • Qingying Xie

  • Zhuoshi Yang

  • Yue Sun

  • Na Zhao

  • Ruirui Hou

  • Zhiyue Di

  • Jian Ma

  • September 9, 2026

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  • 1

    This network meta-analysis evaluates the diagnostic efficacy of contrast-enhanced ultrasound (CEUS) combined with other imaging modalities for thyroid nodules.

  • 2

    Twenty-six studies involving 4484 patients and 5022 thyroid nodules were included in the analysis.

  • 3

    CEUS-ultrasound elastography (UE) demonstrated a pooled sensitivity of 0.92 and specificity of 0.83 for distinguishing benign from malignant thyroid nodules.

  • 4

    CEUS-artificial intelligence (AI) showed a pooled sensitivity of 0.95 and specificity of 0.81 for identifying high-risk thyroid nodules.

  • 5

    The study highlights the need for validation of CEUS findings in larger, diverse external cohorts to confirm diagnostic performance.

Original Source(s)

Diagnostic value of contrast-enhanced ultrasound combined with other imaging techniques in differentiating benign and malignant thyroid nodules: a network meta-analysis

  • by Qingying Xie, Zhuoshi Yang, Yue Sun, Na Zhao, Ruirui Hou, Zhiyue Di, Jian Ma

  • September 9, 2026

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