Differentiating Pulmonary Cryptococcosis from Lung Adenocarcinoma Using Intranodular and Perinodular Radiomic Features on Non-Contrast CT: Findings from a Two-Center Investigation

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The study aimed to differentiate pulmonary cryptococcosis (PC) from lung adenocarcinoma (LAC) using radiomic features from non-contrast CT.
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A total of 244 patients with confirmed PC and LAC were analyzed, with a training set and testing set divided at a 7:3 ratio.
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The combined radiomics model achieved the highest diagnostic performance, with an AUC of 0.922 in the testing set.
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The combined model significantly outperformed the clinical model in diagnostic accuracy, while showing no significant difference from intranodular or perinodular models.
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Integrating intranodular and perinodular radiomics features enhances the ability to accurately distinguish between PC and LAC.

Frontiers In Oncology

by Yanfang Deng, Lin Lin, Kaiji Deng, Liqing Xie, Faming Lai, Suhua Zhong, Yunshan Jiang, Yunjing Xue
April 27, 2026

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