Intermittent Theta-Burst Stimulation and Depressive Symptoms in Major Depressive Disorder: A Randomized - Takeaways - MDSpire

Intermittent Theta-Burst Stimulation and Depressive Symptoms in Major Depressive Disorder: A Randomized

  • By

  • Marte C. Ørbo

  • Ole K. Grønli

  • Mats S. Brochs

  • Oddgeir Friborg

  • Torgil Riise Vangberg

  • Runar Selaas

  • Camilla Larsen

  • Matthias Mittner

  • Zsolt Turi

  • Gábor Csifcsák

  • Per M. Aslaksen

  • July 8, 2026

  • 0 min

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  • 1

    Intermittent theta-burst stimulation (iTBS) is a time-efficient alternative to repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD).

  • 2

    The study aimed to evaluate the antidepressant effects of iTBS compared to sham stimulation in adults with MDD through a randomized, double-blind trial.

  • 3

    Participants included adults aged 22-65 years with a clinician-rated Montgomery-Åsberg Depression Rating Scale score of 20 or more.

  • 4

    The stimulation protocol involved 10 sessions of iTBS delivered once daily over 6 weeks to the left dorsolateral prefrontal cortex.

  • 5

    Primary outcomes included differences in depression ratings at day 10, assessed using the MADRS and Beck Depression Inventory–II.

Original Source(s)

Intermittent Theta-Burst Stimulation and Depressive Symptoms in Major Depressive Disorder: A Randomized

  • by Marte C. Ørbo, Ole K. Grønli, Mats S. Brochs, Oddgeir Friborg, Torgil Riise Vangberg, Runar Selaas, Camilla Larsen, Matthias Mittner, Zsolt Turi, Gábor Csifcsák, Per M. Aslaksen

  • July 8, 2026

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