Mass Spec Roundup: Oocytes, Ligands, Ion Traps, and Corals

From single-oocyte glycans to Maui coral stress, new studies show mass spectrometry extending its reach across scale, chemistry, and environment

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The seGRAP workflow enables single-oocyte N-glycome profiling on routine mass spectrometry platforms with minimal sample loss.
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Single-oocyte analysis identified 46 N-glycan compositions, revealing a conserved glycan repertoire across donors and maturation stages.
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Dynamic combinatorial libraries and activity-based protein profiling enhance covalent ligand discovery throughput by 10- to 20-fold.
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A software-defined retrofit restored mass analysis and multistage fragmentation to a legacy linear ion trap for training purposes.
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The retrofit demonstrated multistage tandem mass spectrometry capabilities, isolating and activating ions without changing trapping voltage.

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