Steroid Pulse Therapy Benefits GFAP Astrocytopathy

Marked clinical and MRI improvement reported in a single-patient case.

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High-dose corticosteroid therapy led to significant clinical and neuroimaging improvement in a patient with autoimmune GFAP astrocytopathy.
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The patient, a 19-year-old woman, exhibited subacute meningoencephalitic symptoms and characteristic MRI findings.
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Cerebrospinal fluid analysis revealed lymphocytic pleocytosis with elevated protein and pressure, supporting the diagnosis.
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Diagnosis of GFAP astrocytopathy relies on detecting GFAP antibodies in cerebrospinal fluid alongside clinical and imaging findings.
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Tumor screening is advised post-diagnosis due to the potential association of GFAP astrocytopathy with underlying malignancies.

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