Case Report: Paradoxical psoriasis under TNF-α blockade may represent generalized abscessing staphyloderma – GASD syndrome by TNF antagonists - Takeaways - MDSpire
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Case Study: The Development of Paradoxical Psoriasis During TNF-α Inhibition May Indicate Generalized Abscessing Staphyloderma – GASD Syndrome Associated with TNF Blockers

  • By

  • Jörg C. Prinz

  • Pia-Charlotte Stadler

  • June 9, 2026

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  • 1

    Patients on TNF-α antagonists can develop paradoxical psoriasis-like skin lesions due to impaired antimicrobial immunity.

  • 2

    Paradoxical psoriasis includes various skin manifestations such as pustular lesions, inflammatory nodules, and nonscarring alopecia.

  • 3

    The study reviewed six patients initially diagnosed with paradoxical psoriasis, revealing generalized abscessing staphyloderma instead.

  • 4

    Skin lesions in these patients were linked to Staphylococcus aureus, likely spreading from nasal colonization.

  • 5

    Topical antimicrobial therapy and systemic antibiotics effectively resolved the skin symptoms in the reviewed cases.

Original Source(s)

Case Report: Paradoxical psoriasis under TNF-α blockade may represent generalized abscessing staphyloderma – GASD syndrome by TNF antagonists

  • by Jörg C. Prinz, Pia-Charlotte Stadler

  • June 9, 2026

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