Case report: Recurrence of anti-myeloperoxidase pauci-immune crescentic glomerulonephritis in a kidney transplant recipient; potential association with HLA antigens and seropositivity? - Takeaways - MDSpire

Case report: Recurrence of anti-myeloperoxidase pauci-immune crescentic glomerulonephritis in a kidney transplant recipient; potential association with HLA antigens and seropositivity?

  • By

  • Woojin James Chon

  • Choli Hartono

  • Elena-Rodica Vasilescu

  • David Serur

  • Ibrahim Batal

  • June 17, 2026

  • 0 min

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  • 1

    Early recurrence of anti-MPO AAV in a kidney transplant patient was linked to shared HLA-DR4 and HLA-DQ7 antigens with the donor.

  • 2

    The patient had elevated anti-MPO antibodies post-transplantation, indicating a potential risk factor for recurrence.

  • 3

    Despite immunosuppressive therapy, the patient developed recurrent pauci-immune crescentic glomerulonephritis shortly after transplantation.

  • 4

    The kidney allograft biopsy revealed findings consistent with recurrent pauci-immune focal crescentic GN.

  • 5

    Close monitoring for disease recurrence is crucial in kidney transplant patients with a history of anti-MPO AAV.

Original Source(s)

Case report: Recurrence of anti-myeloperoxidase pauci-immune crescentic glomerulonephritis in a kidney transplant recipient; potential association with HLA antigens and seropositivity?

  • by Woojin James Chon, Choli Hartono, Elena-Rodica Vasilescu, David Serur, Ibrahim Batal

  • June 17, 2026

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