Case Report: Elastography-negative acute fatty liver of pregnancy diagnosed by histopathology and electron microscopy - Takeaways - MDSpire

Case Report: Elastography-negative acute fatty liver of pregnancy diagnosed by histopathology and electron microscopy

  • By

  • Takuto Nosaka

  • Arisa Saito

  • Yu Akazawa

  • Kazuto Takahashi

  • Tatsushi Naito

  • Masahiro Ohtani

  • Yoshiaki Imamura

  • Sho Kudo

  • Makoto Orisaka

  • Yoshio Yoshida

  • Yasunari Nakamoto

  • June 15, 2026

  • 0 min

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  • 1

    Acute fatty liver of pregnancy (AFLP) is a rare but serious condition that can lead to multiorgan failure and has a maternal mortality rate of 16.5 to 26.7%.

  • 2

    Imaging modalities like CT and ultrasound may suggest AFLP, but their diagnostic roles are not well defined, particularly for microvesicular steatosis.

  • 3

    In this case, a 29-year-old woman developed AFLP at 33 weeks of gestation, presenting with jaundice, liver dysfunction, coagulopathy, and renal impairment.

  • 4

    Histological examination via liver biopsy confirmed microvesicular steatosis, while elastography underestimated hepatic fat accumulation.

  • 5

    The case highlights the importance of detailed pathological evaluation for accurate diagnosis of AFLP, especially when imaging results are inconclusive.

Original Source(s)

Case Report: Elastography-negative acute fatty liver of pregnancy diagnosed by histopathology and electron microscopy

  • by Takuto Nosaka, Arisa Saito, Yu Akazawa, Kazuto Takahashi, Tatsushi Naito, Masahiro Ohtani, Yoshiaki Imamura, Sho Kudo, Makoto Orisaka, Yoshio Yoshida, Yasunari Nakamoto

  • June 15, 2026

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