Recombinant TadZ from the type IVc pilus system induces protective immunity against virulent Aeromonas hydrophila in channel catfish (Ictalurus punctatus) - Takeaways - MDSpire

Recombinant TadZ from the type IVc pilus system induces protective immunity against virulent Aeromonas hydrophila in channel catfish (Ictalurus punctatus)

  • By

  • Young Kyung Park

  • Fenny Patel

  • Hossam Abdelhamed

  • Larry A. Hanson

  • Mark L. Lawrence

  • Hasan C. Tekedar

  • May 7, 2026

  • 0 min

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  • 1

    Recombinant TadZ from Aeromonas hydrophila significantly reduces mortality in channel catfish after immunization and subsequent challenge with virulent strains.

  • 2

    Immunization with TadZ resulted in a relative percent survival of 67.2%, decreasing mortality from 79.6% in non-immunized fish to 26.1%.

  • 3

    TadZ immunization elicited robust humoral immune responses, evidenced by significantly elevated IgM titers against both TadZ and wild-type antigens.

  • 4

    The study highlights TadZ as a conserved and essential component of the Tad pilus system, relevant for vaccine development against Aeromonas hydrophila.

  • 5

    Findings support further evaluation of TadZ as a promising antigen for vaccines, addressing the challenges of antigenic diversity in A. hydrophila.

Original Source(s)

Recombinant TadZ from the type IVc pilus system induces protective immunity against virulent Aeromonas hydrophila in channel catfish (Ictalurus punctatus)

  • by Young Kyung Park, Fenny Patel, Hossam Abdelhamed, Larry A. Hanson, Mark L. Lawrence, Hasan C. Tekedar

  • May 7, 2026

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