The effect of frequent plasmapheresis in a patient with anti-glomerular basement membrane antibody diseases with severe renal dysfunction: a case report and literature review - Takeaways - MDSpire

The effect of frequent plasmapheresis in a patient with anti-glomerular basement membrane antibody diseases with severe renal dysfunction: a case report and literature review

  • By

  • Huimin Tian

  • Qian Ren

  • Hongyu Qiu

  • Shenju Gou

  • June 12, 2026

  • 0 min

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  • 1

    Anti-GBM disease is a rare autoimmune disorder leading to severe kidney and lung complications, often resulting in poor patient outcomes.

  • 2

    Plasmapheresis combined with immunosuppressive therapy can improve renal function in critically ill anti-GBM patients with severe disease.

  • 3

    The reported case involved a 26-year-old woman with severe renal impairment who achieved normal kidney function after persistent plasmapheresis.

  • 4

    The patient's treatment included 25 rounds of plasmapheresis, which continued until the complete clearance of pathogenic autoantibodies.

  • 5

    Early and sustained plasmapheresis may offer a potential rescue for kidney function in patients with anti-GBM disease and extremely poor prognosis.

Original Source(s)

The effect of frequent plasmapheresis in a patient with anti-glomerular basement membrane antibody diseases with severe renal dysfunction: a case report and literature review

  • by Huimin Tian, Qian Ren, Hongyu Qiu, Shenju Gou

  • June 12, 2026

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