Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review - Takeaways - MDSpire

Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review

  • By

  • Mikołaj Kisiała

  • Wiktoria Mazepa

  • Dominika Bauer

  • Patrycja Tabaka

  • Michał Gas

  • Aleksander Sowiński

  • Krzysztof Wolak

  • Albert Synal

  • Julia Gąsiorowska

  • Oliwia Sas

  • Wojciech Urbański

  • Oliwier Pioterek

  • Mateusz Mazurek

  • Zygmunt Domagała

  • April 13, 2026

  • 0 min

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  • 1

    Polycystic ovary syndrome (PCOS) affects 6-13% of reproductive-age women and is characterized by insulin resistance and impaired carbohydrate metabolism.

  • 2

    Insulin resistance in PCOS occurs in 75-95% of affected women, significantly increasing risks for type 2 diabetes and cardiovascular disease.

  • 3

    The review identifies key molecular mechanisms of insulin resistance in PCOS, including defects in IRS/PI3K/AKT signaling and GLUT4 dysfunction.

  • 4

    Current evidence on insulin resistance mechanisms in PCOS is largely derived from animal models, with limited human studies available.

  • 5

    Further high-quality longitudinal research is needed to validate mechanisms of insulin resistance and carbohydrate metabolism in PCOS.

Original Source(s)

Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review

  • by Mikołaj Kisiała, Wiktoria Mazepa, Dominika Bauer, Patrycja Tabaka, Michał Gas, Aleksander Sowiński, Krzysztof Wolak, Albert Synal, Julia Gąsiorowska, Oliwia Sas, Wojciech Urbański, Oliwier Pioterek, Mateusz Mazurek, Zygmunt Domagała

  • April 13, 2026

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