Prognostic Significance and Temporal Patterns of Glycemic Variability in Critically Ill Non-Diabetic Patients with Ischemic Stroke: A Retrospective Multicenter Cohort Study - Takeaways - MDSpire

Prognostic Significance and Temporal Patterns of Glycemic Variability in Critically Ill Non-Diabetic Patients with Ischemic Stroke: A Retrospective Multicenter Cohort Study

  • By

  • Sang, Jiani

  • Li, Weizhao

  • Feng, Zhaoyang

  • Kang, Jiale

  • Niu, Danyang

  • Liu, Junjie

  • May 14, 2026

  • 0 min

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  • 1

    Glycemic variability (GV) is a significant predictor of all-cause mortality in critically ill non-diabetic ischemic stroke patients.

  • 2

    The study analyzed 2,971 ND-IS patients across multiple centers, revealing a progressive increase in mortality with higher GV quartiles.

  • 3

    High GV was independently associated with increased mortality risk at 28 and 365 days, with hazard ratios of 1.31 and 1.49, respectively.

  • 4

    Mortality risk increased steeply beyond a GV of 16-18% and plateaued around 36-38%, indicating a nonlinear relationship.

  • 5

    Incorporating GV into traditional severity models enhanced long-term prognostic accuracy for critically ill ND-IS patients.

Original Source(s)

Prognostic Significance and Temporal Patterns of Glycemic Variability in Critically Ill Non-Diabetic Patients with Ischemic Stroke: A Retrospective Multicenter Cohort Study

  • by Sang, Jiani , Li, Weizhao , Feng, Zhaoyang , Kang, Jiale , Niu, Danyang , Liu, Junjie

  • May 14, 2026

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