Opportunistic osteoporosis assessment from routine CT—effect of intravenous contrast agents on absolute values, T-scores, and derived classifications in single- and dual-energy CT

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Osteoporosis significantly impacts global health, increasing fracture risk and healthcare costs as the population ages.
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Dual-energy X-ray absorptiometry (DEXA) is commonly used for diagnosing osteoporosis but has limitations in precision and applicability.
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Quantitative CT (QCT) provides accurate volumetric assessments of bone density but is less feasible for retrospective analysis.
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This study investigates the effect of intravenous contrast agents on bone density measurements in CT scans.
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Automated segmentation and BMD estimation were performed on CT images to derive T-scores without using DEXA as a reference.

European Radiology

by Jennifer Gotta, Vitali Koch, Scherwin Mahmoudi, Simon S. Martin, Jan Erik Scholtz, Christian Booz, Katrin Eichler, Simon Bernatz, Philipp Reschke, Tatjana Gruber-Rouh, Tommaso D’Angelo, Thomas J. Vogl, Leon D. Gruenewald
September 11, 2025

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