Small Bowel Perforation in Roux-en-Y Gastric Bypass (RYGB) Secondary to Apolipoprotein A-IV (AApoA-IV) Type Amyloidosis - Takeaways - MDSpire

Small Bowel Perforation in Roux-en-Y Gastric Bypass (RYGB) Secondary to Apolipoprotein A-IV (AApoA-IV) Type Amyloidosis

  • By

  • Mona Zhi Ling Mai Jiang

  • Stefaan De Clercq

  • March 29, 2025

  • 0 min

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  • 1

    Amyloidosis can cause small bowel perforation in patients with inflammatory bowel disease (IBD) undergoing Roux-en-Y gastric bypass (RYGB).

  • 2

    A 50-year-old woman with Crohn's disease experienced small bowel perforation due to apolipoprotein A-IV type amyloidosis after RYGB surgery.

  • 3

    Histopathological analysis of the perforated bowel revealed amyloidosis, confirmed by Congo red staining and liquid chromatography-mass spectrometry.

  • 4

    The patient's post-operative recovery was uneventful, and she reported minimal symptoms 16 months after the revision surgery.

  • 5

    Bariatric surgery in IBD patients requires careful consideration of risks, as complication rates are comparable to non-IBD patients.

Original Source(s)

Small Bowel Perforation in Roux-en-Y Gastric Bypass (RYGB) Secondary to Apolipoprotein A-IV (AApoA-IV) Type Amyloidosis

  • by Mona Zhi Ling Mai Jiang, Stefaan De Clercq

  • March 29, 2025

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