Subclinical ocular alterations in Graves' disease: The FUMO score, a new tool to predict Graves' orbitopathy progression - Takeaways - MDSpire

Subclinical ocular alterations in Graves' disease: The FUMO score, a new tool to predict Graves' orbitopathy progression

  • By

  • Giulia Lanzolla

  • Francesca Saba

  • Silvia Corrias

  • Filippo Lixi

  • Giulia Faa

  • Alessandro Colleo

  • Chiara Mura

  • Gian Luigi Canu

  • Federico Cappellacci

  • Alberto Cuccu

  • Giuseppe Giannaccare

  • Stefano Mariotti

  • Francesco Boi

  • February 2, 2026

  • 0 min

Share

  • 1

    The FUMO score predicts the onset of overt Graves' orbitopathy (GO) in patients with Graves' disease (GD) using visual function tests and orbital ultrasound.

  • 2

    Patients with a medium-high FUMO score developed overt GO more frequently than those with a low-risk score after 24 months.

  • 3

    TRAb levels and the FUMO score were identified as strong independent predictors of GO, alongside higher FT3 levels and smoking.

  • 4

    The FUMO score demonstrated good calibration and discrimination, with an AUC of 0.84 and high predictive values for GO.

  • 5

    Subclinical ocular changes in GD patients can effectively indicate the risk of developing overt GO, aiding in early risk stratification.

Original Source(s)

Subclinical ocular alterations in Graves' disease: The FUMO score, a new tool to predict Graves' orbitopathy progression

  • by Giulia Lanzolla, Francesca Saba, Silvia Corrias, Filippo Lixi, Giulia Faa, Alessandro Colleo, Chiara Mura, Gian Luigi Canu, Federico Cappellacci, Alberto Cuccu, Giuseppe Giannaccare, Stefano Mariotti, Francesco Boi

  • February 2, 2026

Related Content

HPV Linked to Thyroid Eye Disease

Patients with the eye disorder were more likely to have had low-risk HPV before hyperthyroidism diagnosis.

Who Decides When a Doctor Steps Back?

Cognitive decline, credentialing, and why “I’ll know” often isn’t enough.

Evaluating AI for thyroid nodule diagnosis

Ultrasound based AI–assisted diagnostic systems “demonstrated high clinical potential."