Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models - Takeaways - MDSpire

Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models

  • By

  • Xiangyun Chen

  • Yihe Xu

  • Yonghong Gao

  • Xinxing Lai

  • Rufan Xu

  • Hongrui Zhang

  • Na Li

  • Zhenhong Liu

  • Ying Gao

  • July 16, 2026

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  • 1

    Stroke-associated pneumonia (SAP) significantly increases mortality after stroke due to stroke-induced immunosuppression.

  • 2

    A systematic review included 38 studies that explored immune mechanisms and immunomodulatory therapies for SAP.

  • 3

    Systemic immunosuppression in SAP is primarily driven by sympathetic nervous system overactivation and splenic atrophy.

  • 4

    Disruption of the gut-lung axis and local pulmonary alterations are implicated in the development of SAP.

  • 5

    Emerging immunomodulatory interventions targeting these mechanisms show promise in preclinical models but require further validation.

Original Source(s)

Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models

  • by Xiangyun Chen, Yihe Xu, Yonghong Gao, Xinxing Lai, Rufan Xu, Hongrui Zhang, Na Li, Zhenhong Liu, Ying Gao

  • July 16, 2026

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