Clinical implications of plasma sADAM10: integrating renal function, histopathology and prognostic outcomes in chronic kidney disease and kidney transplantation

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Plasma soluble ADAM10 (sADAM10) levels are significantly higher in kidney transplant recipients and chronic kidney disease patients compared to healthy controls.
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In chronic kidney disease, plasma sADAM10 is independently associated with estimated glomerular filtration rate (eGFR), while in kidney transplant recipients, it correlates with neutrophil count.
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Higher plasma sADAM10 levels are linked to increased severity of interstitial fibrosis and tubular atrophy, tubular injury, and interstitial inflammation.
4

Plasma sADAM10 provides incremental prognostic value for post-transplant infection risk beyond traditional markers like age and eGFR.
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The association of plasma sADAM10 with renal outcomes is confounded by eGFR, indicating its context-dependent prognostic value.

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