Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder - Takeaways - MDSpire
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Association of Disease Severity with Longitudinal Changes in Gray Matter Volume in Individuals Diagnosed with Major Depressive Disorder

  • By

  • Anna Kraus

  • Janik Goltermann

  • Tiana Borgers

  • Katharina Dohm

  • Dominik Grotegerd

  • Elisabeth Schrammen

  • Kira Flinkenflügel

  • Verena Enneking

  • Elisabeth J. Leehr

  • Joscha Böhnlein

  • Nils Winter

  • Alea Bexten

  • Tim Hahn

  • Jochen Bauer

  • Marius Gruber

  • Jonathan Repple

  • Katharina Förster

  • Eva Mennigen

  • Nils Opel

  • Tilo Kircher

  • Susanne Meinert

  • Udo Dannlowski

  • September 14, 2026

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  • 1

    Longitudinal studies indicate that gray matter volume (GMV) alterations in major depressive disorder (MDD) vary over time.

  • 2

    Research shows larger GMV decreases linked to failed remission, relapse, and rehospitalization in specific brain regions.

  • 3

    The study aimed to investigate individual GMV trajectories in MDD over up to 10 years with multiple MRI assessments.

  • 4

    Cumulative illness severity (CIS) was evaluated alongside acute depressive state to distinguish between persistent and dynamic brain changes.

  • 5

    The study was approved by the ethics committee of the Medical Faculty of University of Münster, with informed consent obtained from all participants.

Original Source(s)

Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder

  • by Anna Kraus, Janik Goltermann, Tiana Borgers, Katharina Dohm, Dominik Grotegerd, Elisabeth Schrammen, Kira Flinkenflügel, Verena Enneking, Elisabeth J. Leehr, Joscha Böhnlein, Nils Winter, Alea Bexten, Tim Hahn, Jochen Bauer, Marius Gruber, Jonathan Repple, Katharina Förster, Eva Mennigen, Nils Opel, Tilo Kircher, Susanne Meinert, Udo Dannlowski

  • September 14, 2026

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