Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals - Takeaways - MDSpire

Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals

  • By

  • Rebecca Z. Rousset

  • Madison I. J. Honey

  • Anouk den Braber

  • Wiesje M. van der Flier

  • Henne Holstege

  • Linda Lorenz

  • Mark H. J. Wessels

  • Joep Killestein

  • Martijn Huisman

  • Almar Kok

  • Marian Beekman

  • P. Eline Slagboom

  • Lannie Ligthart

  • Eco de Geus

  • Inge M. W. Verberk

  • Lisa Vermunt

  • Charlotte E. Teunissen

  • May 14, 2026

  • 0 min

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  • 1

    GFAP and NfL are biomarkers for astrocyte and axonal injury, respectively, released into the bloodstream upon neuronal damage.

  • 2

    NfL concentrations increase with age, while GFAP concentrations also rise in adulthood, but their biological modifiers are less understood.

  • 3

    The study established reference intervals for GFAP and NfL concentrations, accounting for age, sex, kidney function, and BMI.

  • 4

    Validation of reference intervals was performed using an external dataset to ensure generalizability across populations.

  • 5

    An interactive interface was developed to assist clinicians in interpreting GFAP and NfL concentrations in individual contexts.

Original Source(s)

Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals

  • by Rebecca Z. Rousset, Madison I. J. Honey, Anouk den Braber, Wiesje M. van der Flier, Henne Holstege, Linda Lorenz, Mark H. J. Wessels, Joep Killestein, Martijn Huisman, Almar Kok, Marian Beekman, P. Eline Slagboom, Lannie Ligthart, Eco de Geus, Inge M. W. Verberk, Lisa Vermunt, Charlotte E. Teunissen

  • May 14, 2026

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