Effect modification by chronic obstructive pulmonary disease, anion gap, and serum creatinine on the association between invasive mechanical ventilation and 28-day mortality in intensive care unit sepsis patients: a retrospective cohort study - Takeaways - MDSpire

Effect modification by chronic obstructive pulmonary disease, anion gap, and serum creatinine on the association between invasive mechanical ventilation and 28-day mortality in intensive care unit sepsis patients: a retrospective cohort study

  • By

  • Yan Xue

  • Shao-Xiong Chen

  • Guo-Ren Chen

  • Wei Lin

  • Xing-Feng Yu

  • Hao Lin

  • Ran Chen

  • May 27, 2026

  • 0 min

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  • 1

    Mechanical ventilation (MV) is independently associated with increased 28-day mortality in ICU sepsis patients.

  • 2

    The 28-day mortality rate was significantly higher in patients receiving MV compared to those who did not.

  • 3

    Chronic obstructive pulmonary disease (COPD), anion gap, and serum creatinine significantly modify the MV-mortality association.

  • 4

    Patients with an elevated anion gap showed a pronounced adverse association with MV and mortality.

  • 5

    These findings emphasize the need for individualized assessment and tailored respiratory management strategies in sepsis patients.

Original Source(s)

Effect modification by chronic obstructive pulmonary disease, anion gap, and serum creatinine on the association between invasive mechanical ventilation and 28-day mortality in intensive care unit sepsis patients: a retrospective cohort study

  • by Yan Xue, Shao-Xiong Chen, Guo-Ren Chen, Wei Lin, Xing-Feng Yu, Hao Lin, Ran Chen

  • May 27, 2026

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