Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer’s disease - Takeaways - MDSpire

Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer’s disease

  • By

  • Yali Chen

  • Xia Zhou

  • Kaigui Wang

  • He Feng

  • Bo Tian

  • Yating Tang

  • Xiaoqun Zhu

  • Zhongwu Sun

  • May 11, 2026

  • 0 min

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  • 1

    Dysfunction in one-carbon metabolism and the glymphatic system is linked to Alzheimer's disease pathogenesis.

  • 2

    Serum folate levels and DTI-ALPS index significantly differ between normal cognition and Alzheimer's disease groups.

  • 3

    In Alzheimer's patients, higher folate levels correlate positively with glymphatic function and cognitive performance.

  • 4

    Low serum folate and reduced glymphatic function are associated with poorer cognitive outcomes in Alzheimer's disease.

  • 5

    The study suggests a potential link between metabolic status and glymphatic function in Alzheimer's, warranting further research.

Original Source(s)

Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer’s disease

  • by Yali Chen, Xia Zhou, Kaigui Wang, He Feng, Bo Tian, Yating Tang, Xiaoqun Zhu, Zhongwu Sun

  • May 11, 2026

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