Upgrading Housing-First Interventions in the Age of Fentanyl - Takeaways - MDSpire

Upgrading Housing-First Interventions in the Age of Fentanyl

  • By

  • Karen Drexler

  • May 5, 2026

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  • 1

    Opioid use disorder (OUD) significantly increases overdose mortality rates among people experiencing homelessness (PEH).

  • 2

    Medications for opioid use disorder (MOUD) are critical for reducing mortality risk and are recommended as first-line treatment by health authorities.

  • 3

    The housing-first model improves housing retention but does not demonstrate reduced mortality or improved substance use outcomes among PEH with OUD.

  • 4

    Only 17% of veterans in the HUD-VASH housing-first program received MOUD, highlighting significant barriers to treatment access.

  • 5

    Integrating addiction specialists and training case managers in motivational interviewing could enhance treatment engagement and survival for individuals with OUD.

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