Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis - Takeaways - MDSpire

Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis

  • By

  • Zisheng Liu

  • Xidong Wu

  • Jiaming Xu

  • Jianyong Cai

  • Huajun Ba

  • Qun Lin

  • Jun Sun

  • Weizhong Shi

  • May 22, 2026

  • 0 min

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  • 1

    Metabolic syndrome (MetS) was more prevalent in patients with ruptured intracranial aneurysms compared to those with unruptured aneurysms.

  • 2

    Binary MetS was independently associated with ruptured aneurysm status, with an adjusted odds ratio of 1.83.

  • 3

    Higher MetS scores showed a graded association with ruptured status, indicating a potential link between MetS burden and aneurysm rupture.

  • 4

    Individual components of MetS, particularly elevated glucose and reduced HDL cholesterol, demonstrated the strongest associations with ruptured status.

  • 5

    The findings suggest that MetS may influence aneurysm stability, warranting further prospective multicenter validation.

Original Source(s)

Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis

  • by Zisheng Liu, Xidong Wu, Jiaming Xu, Jianyong Cai, Huajun Ba, Qun Lin, Jun Sun, Weizhong Shi

  • May 22, 2026

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