Sex chromosomes and cardiovascular disease

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Sex differences in cardiovascular disease (CVD) are influenced by both hormonal factors and sex chromosomes.
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Mosaic loss of the Y chromosome (mLoY) is linked to CVD, particularly in heart failure and myocardial fibrosis.
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X chromosome inactivation escape may explain sex differences in CVD by leading to higher expression of specific X-linked genes in females.
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Understanding sex chromosome-related mechanisms is crucial for elucidating disease susceptibility and treatment responses in CVD.
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Research on sex chromosomes in CVD has been limited, necessitating further studies to clarify their role in disease aetiology.

European Journal Of Preventive Cardiology

by Anna E Spiering, Phebe J Groenheide, Michal Mokry, N Charlotte Onland-Moret, Mete Civelek, Karen Reue, Ernest Diez Benavente, Hester M den Ruijter
April 15, 2025

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