Plasma levels of soluble Flt-1 and Tie-2 correlate with neovascularization in human carotid atherosclerotic plaques – a pilot study - Takeaways - MDSpire

Association of Plasma Soluble Flt-1 and Tie-2 Levels with Neovascularization in Atherosclerotic Carotid Plaques: A Preliminary Investigation

  • By

  • Mahtab Zamani

  • Karolina Skagen

  • Beate Lindberg

  • Vigdis Bjerkeli

  • Tuva B. Dahl

  • Annika Elisabeth Michelsen

  • Thor Ueland

  • Pål Aukrust

  • Bente Halvorsen

  • Mona Skjelland

  • July 21, 2026

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  • 1

    The study investigated the association of plasma soluble Flt−1 and Tie−2 levels with intraplaque neovascularization in carotid atherosclerotic plaques.

  • 2

    IPN was detected in 75% of patients, with plasma sFlt−1 showing a significant correlation with neovessel counts measured by SMI.

  • 3

    Histological analysis revealed that sFlt−1 correlated with neovessel counts, while sTie−2 did not demonstrate a significant relationship.

  • 4

    Single-cell RNA-seq data indicated that FLT1 and ANGPT2 were expressed across various plaque cell populations, supporting local signaling pathways.

  • 5

    Higher plasma sFlt−1 levels were independently associated with intraplaque neovascularization, suggesting its potential as a marker of plaque vulnerability.

Original Source(s)

Plasma levels of soluble Flt-1 and Tie-2 correlate with neovascularization in human carotid atherosclerotic plaques – a pilot study

  • by Mahtab Zamani, Karolina Skagen, Beate Lindberg, Vigdis Bjerkeli, Tuva B. Dahl, Annika Elisabeth Michelsen, Thor Ueland, Pål Aukrust, Bente Halvorsen, Mona Skjelland

  • July 21, 2026

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