Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia - Takeaways - MDSpire

Zinc's Role in Type 2 Diabetes and Diabetic Kidney Disease: Emphasis on Hypoxia

  • By

  • Svetlana A. Lebedeva

  • Ekaterina M. Mikhailova

  • Maria Yu Materenchuk

  • Denis V. Kurkin

  • Mikhail Samsonov

  • Vadim V. Tarasov

  • Kerim Mutig

  • July 21, 2026

Share

  • 1

    Type 2 diabetes mellitus is a major global health issue, with projections of 640 million affected individuals by 2045.

  • 2

    Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease, affecting 30-40% of individuals with type 2 diabetes.

  • 3

    Zinc signaling is crucial for the adaptive cellular response to hypoxia, promoting the expression of hypoxia-inducible factor-1α (HIF-1α).

  • 4

    Zinc deficiency can impair insulin synthesis and secretion, contributing to insulin resistance and potentially increasing diabetes risk.

  • 5

    Zinc supplementation has been shown to reduce blood glucose levels and improve insulin responsiveness in individuals with diabetes.

Original Source(s)

Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia

  • by Svetlana A. Lebedeva, Ekaterina M. Mikhailova, Maria Yu Materenchuk, Denis V. Kurkin, Mikhail Samsonov, Vadim V. Tarasov, Kerim Mutig

  • July 21, 2026

Related Content

Integrating telemedicine into nutritional management of infants with inherited metabolic disorders: a pilot study

Editorial: Sex hormones and cardiovascular-renal health: mechanisms, consequences, and therapeutic insights

An FDG-first functional imaging approach in phaeochromocytoma and paraganglioma