Study on the stability of antipsychotic drugs in clinical samples within serum collection tubes with and without separating gel - Takeaways - MDSpire

Evaluation of Antipsychotic Drug Stability in Clinical Serum Samples from Blood Collection Tubes With and Without Separation Gel

  • By

  • Wenjuan Dong

  • Xin Cheng

  • Zhi Chu

  • Haifeng Zhang

  • Jing He

  • Xue Zhang

  • July 17, 2026

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  • 1

    The study evaluated antipsychotic drug loss in serum samples from blood collection tubes with and without separation gel.

  • 2

    Clozapine and aripiprazole concentrations were significantly lower in separation-gel tubes compared to non-gel tubes on Day 0.

  • 3

    Clozapine remained stable in non-gel tubes during refrigerated storage, while it decreased in gel tubes over 7 days.

  • 4

    Aripiprazole showed an initial concentration difference in gel tubes but no further loss during refrigerated storage.

  • 5

    Most analytes showed no clinically relevant concentration loss during 7 days of refrigerated storage under tested conditions.

Original Source(s)

Study on the stability of antipsychotic drugs in clinical samples within serum collection tubes with and without separating gel

  • by Wenjuan Dong, Xin Cheng, Zhi Chu, Haifeng Zhang, Jing He, Xue Zhang

  • July 17, 2026

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