Comparative effectiveness of single-stage versus two-stage revision for hip prosthetic joint infection: emulation of the INFORM target trial using electronic health record data - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Effectiveness Comparison of Single-Stage and Two-Stage Revision Strategies for Hip Prosthetic Joint Infections: Insights from an INFORM Target Trial Emulation Utilizing Electronic Health Records

  • By

  • Changqing Zhang

  • Yusheng Li

  • Chi Su

  • Yun Shen

  • Shengdi Lu

  • September 6, 2026

Share

  • 1

    Prosthetic joint infection (PJI) occurs in 1% to 2% of total hip arthroplasties and is associated with significant morbidity and economic burden.

  • 2

    The INFORM trial, published in 2022, was the first randomized controlled trial comparing single-stage and two-stage revision strategies for hip PJI.

  • 3

    At 3 months, single-stage revision showed superior function and fewer intraoperative adverse events compared to two-stage revision.

  • 4

    The study emulated the INFORM trial using electronic health records from three Chinese hospitals to assess the effectiveness of revision strategies.

  • 5

    Differences in patient demographics and microbiological characteristics may affect the applicability of INFORM trial results to Chinese hospitals.

Original Source(s)

Comparative effectiveness of single-stage versus two-stage revision for hip prosthetic joint infection: emulation of the INFORM target trial using electronic health record data

  • by Changqing Zhang, Yusheng Li, Chi Su, Yun Shen, Shengdi Lu

  • September 6, 2026

Related Content

Robotic knee surgery put to the test

RACER-Knee compared Mako-assisted and conventional total knee replacement across 10 hospitals in Great Britain.

Educators weigh how to use AI without losing critical thinking

Greater productivity is not necessarily indicative of greater knowledge.

Favorable clinical and microbiological outcomes of a war-associated prosthetic joint infection caused by Klebsiella pneumoniae treated with combined phage-colistin therapy